反応 #48905

反応方程式

4-Methylbenzene-1-sulfonyl chloride

8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one

pyridine

→

8-(cyclopentyloxy)-7-methoxy-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

溶媒

dichloromethane

反応条件

後処理

1. 1
   濃縮the reaction was concentrated
2. 2
   その他purified by silica gel chromatography (1:0→7:3; hexanes:ethyl acetate)

実験手順

4-Methylbenzene-1-sulfonyl chloride (135 mg, 0.71 mmol) was added to a solution of 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one (175 mg, 0.63 mmol), pyridine (0.15 mL, 1.85 mmol), and anhydrous dichloromethane (4 mL) at rt under N2. After 20 h, the reaction was concentrated and purified by silica gel chromatography (1:0→7:3; hexanes:ethyl acetate) to give 8-(cyclopentyloxy)-7-methoxy-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate: MS (ESI): 431.3.

出典