反応 #488416

反応方程式

2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester

diphenylether

→

4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

溶媒

n-hexane

反応条件

後処理

1. 1
   温度was refluxed for 15 min
2. 2
   温度After cooling
3. 3
   その他The resulting solid was isolated via filtration
4. 4
   その他recrystallized from methanol

実験手順

A mixture of 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (2.8 g, 1 mmol) and diphenylether (20 mL) was refluxed for 15 min. After cooling, n-hexane (80 mL) was added. The resulting solid was isolated via filtration and recrystallized from methanol to give 4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (1.7 g 72%).

出典