反応 #48826

反応方程式

Trimethylsilyl iodide

tert-butyl 3-({3-[4-(ethoxycarbonyl)phenoxy]-5-[(1S)-2-methoxy-1-methylethoxy]benzoyl}amino)-1H-pyrazole-1-carboxylate

Sodium thiosulfate

→

oil

収率 111.3%

Ethyl 4-{3-[(S)-2-hydroxy-1-methylethoxy]-5-[(1H-pyrazol-3-ylamino)carbonyl]phenoxy}benzoate

収率 111.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他to quench
2. 2
   その他the reaction
3. 3
   抽出the reaction mixture was extracted into ethyl acetate (3×25 mL)
4. 4
   乾燥dried (MgSO4)
5. 5
   濃縮the filtrate was concentrated in vacuo

実験手順

Trimethylsilyl iodide (0.27 mL) was added dropwise under argon to a solution of tert-butyl 3-({3-[4-(ethoxycarbonyl)phenoxy]-5-[(1S)-2-methoxy-1-methylethoxy]benzoyl}amino)-1H-pyrazole-1-carboxylate (167 mg, 0.38 mmol) in acetonitrile (5 mL) and stirred at ambient temperature for 16 hours. Sodium thiosulfate solution was added to quench the reaction and the reaction mixture was extracted into ethyl acetate (3×25 mL). Organic phases were combined and dried (MgSO4) and the filtrate was concentrated in vacuo to give a clear oil (180 mg), which was not purified further.

出典