反応 #48776

反応方程式

methyl 3-[(1S)-2-methoxy-(1-methylethyl)oxy]-5-{[4-(methylsulfonyl)phenyl]oxy}benzoate

sodium hydroxide

→

desired compound

収率 83.0%

3-{(1S)-2-Methoxy-(1-methylethyl)oxy}-5-{[4-(methylsulfonyl)phenyl]oxy}benzoic acid

収率 83.0%

溶媒

THF

反応条件

後処理

1. 1
   その他Most of the organic solvent was removed in vacuo
2. 2
   workup.ADDITIONthe remaining solution was diluted with water (150 mL)
3. 3
   抽出extracted with ethyl acetate (2×100 mL)
4. 4
   洗浄washed with brine
5. 5
   乾燥dried (MgSO4)
6. 6
   その他evaporated

実験手順

A solution of methyl 3-[(1S)-2-methoxy-(1-methylethyl)oxy]-5-{[4-(methylsulfonyl)phenyl]oxy}benzoate (60.9 mmol) in THF (400 mL) was treated with a solution of 1M sodium hydroxide (125 mmol), and the reaction mixture stirred for 13 hours at ambient temperature. Most of the organic solvent was removed in vacuo, and the remaining solution was diluted with water (150 mL). The resulting aqueous solution was acidified to pH4 with 1M citric acid solution, and extracted with ethyl acetate (2×100 mL). The extracts were combined, washed with brine, dried (MgSO4), and evaporated to give the desired compound (83% yield).

出典