反応 #487573

反応方程式

phosphoryl chloride

DMF

barbituric acid

→

2,4,6-trioxohexahydropyrimidine-5-carbaldehyde

反応条件

後処理

1. 1
   温度cooling
2. 2
   温度The mixture is cooled
3. 3
   その他the precipitate is separated off
4. 4
   洗浄rinsed with water
5. 5
   その他dried at 45°
6. 6
   その他giving 2.5 g of “1”

実験手順

9.03 ml of phosphoryl chloride are added dropwise to 2 ml of dry DMF with ice-cooling. 1.5 g of barbituric acid are subsequently added, and the mixture is stirred at 100° for 4 h. The mixture is cooled, poured into ice-water, the precipitate is separated off, rinsed with water and dried at 45°, giving 2.5 g of “1”.

出典