反応 #487566

反応方程式

4-chloro-1H-pyrrolo[2,3-b]pyridine

1-benzyl-N-methylpiperidin-3-amine

→

orange oil

収率 130.0%

N-(1-benzylpiperidin-3-yl)-N-methyl-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-amine

収率 130.0%

反応条件

後処理

1. 1
   その他The reaction mixture was partitioned between ethyl acetate (30 mL) and sat. NaHCO3 (20 mL)
2. 2
   洗浄the organic phase was washed with sat. NaCl
3. 3
   その他dried

実験手順

A sealed melted mixture of 4-chloro-1H-pyrrolo[2,3-b]pyridine (0.18 g, 0.0012 mol) in 1-benzyl-N-methylpiperidin-3-amine (0.50 g, 0.0024 mol) was heated to 200° C. overnight. The reaction mixture was partitioned between ethyl acetate (30 mL) and sat. NaHCO3 (20 mL), and the organic phase was washed with sat. NaCl, then dried and was reduced under vacuum to give 500 mg of orange oil. The product was chromatographed with 7% MeOH/DCM, 0.7% NH4OH to give 192 mg of an orange oil (48.8% yield).

出典