反応 #48755

反応方程式

(R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-butyryloxymethyl-morpholine-4-carboxylic acid tert-butyl ester

hydrogen chloride

1,4-dioxane

→

title compound

収率 100.0%

Butyric acid (2R,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-morpholin-2-ylmethyl ester hydrochloride

収率 100.0%

反応条件

後処理

1. 1
   濃縮Concentrate under reduced pressure

実験手順

To (R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-butyryloxymethyl-morpholine-4-carboxylic acid tert-butyl ester (0.022 g, 0.043 mmol) add 4 M hydrogen chloride in 1,4-dioxane (0.500 mL, 2.00 mmol) and stir for 45 minutes. Concentrate under reduced pressure to give the title compound as an off-white solid (20.0 mg, 100%).

出典