反応 #4872

反応方程式

ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate

sodium hydroxide

→

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

収率 75.1%

溶媒

methanol

反応条件

後処理

1. 1
   温度the mixture is refluxed for 30 minutes
2. 2
   温度under heating
3. 3
   温度After cooling
4. 4
   その他crystalline precipitates
5. 5
   ろ過are collected by filtration
6. 6
   洗浄washed with methanol
7. 7
   その他Crystalline precipitates
8. 8
   ろ過are collected by filtration
9. 9
   その他dried

実験手順

16.0 g of ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are added to a mixture of 160 ml of methanol and 30 ml of an aqueous 2N sodium hydroxide solution, and the mixture is refluxed for 30 minutes under heating. After cooling, crystalline precipitates are collected by filtration and washed with methanol. The crystals are suspended in 30 ml of water. Then, the suspension is adjusted to pH 3 with 2N hydrochloric acid. Crystalline precipitates are collected by filtration and dried. 11.4 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained.

出典