反応 #48673

反応方程式

[(S)-1-benzyloxymethyl-2-(2-iodo-1,1-diphenylethoxy)-ethyl]-carbamic acid tert-butyl ester

sodium hydride

→

desired compound

(S)-5-benzyloxymethyl-2,2-diphenyl-morpholine-4-carboxylic acid tert-butyl ester

溶媒

ethyl acetate

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度Heat
2. 2
   その他reaction mixture to 60° C. for 4 hours
3. 3
   洗浄Wash with water and saturated aqueous sodium chloride
4. 4
   乾燥dry (magnesium sulfate)
5. 5
   ろ過filter
6. 6
   濃縮concentrate
7. 7
   その他Purify on silica gel eluting with 0:100 to 20:80 ethyl acetate

実験手順

To [(S)-1-benzyloxymethyl-2-(2-iodo-1,1-diphenylethoxy)-ethyl]-carbamic acid tert-butyl ester (4.74 g, 8.07 mmol) in N,N-dimethylformamide (70 mL) at room temperature add sodium hydride (0.452 g, 11.3 mmol, 60% dispersion in mineral oil). Heat reaction mixture to 60° C. for 4 hours, cool to room temperature and dilute with ethyl acetate (˜400 mL). Wash with water and saturated aqueous sodium chloride, dry (magnesium sulfate), filter and concentrate. Purify on silica gel eluting with 0:100 to 20:80 ethyl acetate:hexanes to give the desired compound as an oil.

出典