反応 #48600

反応方程式

4-methoxybenzyl chloride

4-iodo-1H-pyrazole-3-carboxylic acid phenylamide

potassium carbonate

→

4-iodo-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide

収率 71.2%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他then evaporated under reduced pressure
2. 2
   その他The residue was partitioned between ethyl acetate and brine
3. 3
   その他the ethyl acetate layer was separated
4. 4
   乾燥dried (MgSO4)
5. 5
   ろ過filtered
6. 6
   その他evaporated
7. 7
   その他The crude material was purified by flash column chromatography
8. 8
   洗浄eluting with 1:3 ethyl acetate/hexane
9. 9
   workup.ADDITIONthe product containing fractions
10. 10
    その他evaporated

実験手順

A solution of 4-iodo-1H-pyrazole-3-carboxylic acid phenylamide (670 mg; 2.14 mmol) in acetonitrile (10 ml) was treated with potassium carbonate (360 mg; 2.57 mmol)) followed by 4-methoxybenzyl chloride (320 μl; 2.35 mmol). The mixture was stirred at room temperature overnight then evaporated under reduced pressure. The residue was partitioned between ethyl acetate and brine; the ethyl acetate layer was separated, dried (MgSO4), filtered and evaporated. The crude material was purified by flash column chromatography eluting with 1:3 ethyl acetate/hexane and the product containing fractions combined and evaporated to give 660 mg of 4-iodo-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide.

出典