反応 #48594

反応方程式

benzaldehyde

malononitrile

ethanol

→

2-benzylidene-but-3-yne nitrile

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度at reflux overnight
3. 3
   温度The reaction was cooled
4. 4
   その他evaporated
5. 5
   その他then purified by flash column chromatography
6. 6
   洗浄eluting with 1:9 ethyl acetate/hexane
7. 7
   workup.ADDITIONthe product containing fractions
8. 8
   その他evaporated

実験手順

To a solution of benzaldehyde (2 g; 18.9 mmol) and malononitrile (1.37 g; 20.7 mmol) in ethanol (40 ml) was added 5 drops of piperidine and the mixture was heated at reflux overnight. The reaction was cooled, evaporated then purified by flash column chromatography eluting with 1:9 ethyl acetate/hexane and the product containing fractions combined and evaporated to give 930 mg of 2-benzylidene-but-3-yne nitrile.

出典