反応 #48592

反応方程式

4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

lithium hydroxide monohydrate

→

4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid

収率 108.1%

溶媒

THF water

反応条件

後処理

1. 1
   その他The THF was removed by evaporation
2. 2
   抽出then extracted with ethyl acetate (20 ml)
3. 3
   乾燥The ethyl acetate layer was dried (MgSC4)
4. 4
   ろ過filtered
5. 5
   その他evaporated

実験手順

A solution of 4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (205 mg; 0.72 mmol) and lithium hydroxide monohydrate (125 mg; 2.9 mmol) in 1:1 THF/water (10 ml) was heated at 60° C. overnight. The THF was removed by evaporation, the aqueous phase acidified with 1M hydrochloric acid then extracted with ethyl acetate (20 ml). The ethyl acetate layer was dried (MgSC4), filtered and evaporated to give 200 mg of 4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid. (LC/MS: [M+H]+ 256.85).

出典