反応 #48568

反応方程式

4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

2,3-dichloropyrazine

→

title compound

収率 19.6%

4-(3-Chloro-pyrazin-2-ylamino)-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

収率 19.6%

反応条件

後処理

1. 1
   その他The crude reaction mixture
2. 2
   その他was purified by flash column chromatography
3. 3
   洗浄eluting with ethyl acetate/hexane (1:3
4. 4
   workup.ADDITIONProduct containing fractions
5. 5
   その他evaporated

実験手順

A mixture of 4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide (50 mg; 0.23 mmol) and 2,3-dichloropyrazine (140 mg; 0.92 mmol) was heated at 150° C. (50W) for 20 minutes in a CEM Discover™ microwave synthesiser. The crude reaction mixture was purified by flash column chromatography eluting with ethyl acetate/hexane (1:3 then 1:2). Product containing fractions were combined and evaporated to give 15 mg of the title compound as a white solid. (LC/MS: Rt 4.06 M+H]+ 332).

出典