反応 #485169

反応方程式

Intermediate 9

(2R,3R,4S,5S)-2-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-5-(3-ethyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol

2-(2-aminoethyl) pyridine

DMSO

2-(2-aminoethyl) pyridine

→

title compound

(2S,3S,4R,5R)-2-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-5-[6-(1-ethyl-propylamino)-2-(2-pyridin-2-yl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol formate

反応条件

後処理

1. 1
   その他The product was purified by Autoprep

実験手順

Intermediate 9 (0.070 g, 0.161 mmol) and 2-(2-aminoethyl) pyridine (0.096 ml, 0.807 mmol) were dissolved in DMSO (0.03 ml) and heated at 80° C. in a sealed vial (eg Reacti vial™), for 46 h, a further portion of 2-(2-aminoethyl) pyridine (0.096 ml, 0.807 mmol) was added after the first 20 h. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a beige solid (0.035 g). LC/MS system B Rt=2.38 min, m/z=524 MH+.

出典