反応 #48498

反応方程式

1-(4-benzylpiperazin-1-yl)piperidin-2-one

→

title compound

収率 97.0%

1-(Piperazin-1-yl)piperidin-2-one

収率 97.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

実験手順

To a solution of 1-(4-benzylpiperazin-1-yl)piperidin-2-one (1.0 g) obtained in Example 8a) in methanol (15 mL) was added 20% palladium hydroxide on carbon (containing 50% water, 0.20 g), and the mixture was stirred at room temperature for 15 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the solvent was distilled off under reduced pressure to obtain the title compound (0.65 g, 97%) as a yellow solid.

出典