反応 #48403

反応方程式

water

Sodium hydride

6-phenylazepan-2-one

2-bromoethyl methyl ether

→

1-(2-Methoxyethyl)-6-phenylazepan-2-one

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the mixture was extracted with ethyl acetate (3×)
2. 2
   洗浄The combined organic extracts were washed with water (3×), saturated brine
3. 3
   乾燥dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

Sodium hydride (60% dispersion in mineral oil; 0.32 g, 8.03 mmol) was added to a solution of 6-phenylazepan-2-one (0.76 g, 4.02 mmol) in N,N-dimethylformamide (15 mL) at 0° C., followed by the addition of 2-bromoethyl methyl ether (0.837 g, 6.03 mmol), and the mixture was allowed to warm to ambient temperature. After 21 h, water was added and the mixture was extracted with ethyl acetate (3×). The combined organic extracts were washed with water (3×), saturated brine, dried over sodium sulfate, filtered and concentrated. MS 248 (M+1).

出典