反応 #48399

反応方程式

N,N-bis(tert-butoxycarbonyl)-5-(2,3-dichlorophenyl)-6-nitro-D-norleucinate

hydrogen

→

title compound

収率 182.1%

Benzyl N2,N2-bis(tert-butoxycarbonyl)-5-(2,3-dichlorophenyl)-D-lysinate

収率 182.1%

溶媒

EtOH

反応条件

後処理

1. 1
   洗浄To an EtOH rinsed (4×5 mL) slurry of Raney Ni (1 mL)
2. 2
   ろ過The reaction was filtered through Celite with more EtOH
3. 3
   濃縮concentrated

実験手順

To an EtOH rinsed (4×5 mL) slurry of Raney Ni (1 mL) was added a solution of benzyl (5R or S)—N,N-bis(tert-butoxycarbonyl)-5-(2,3-dichlorophenyl)-6-nitro-D-norleucinate (0.52 g, 0.85 mmol) in EtOH (5 mL). This slurry was hydrogenated under a balloon of hydrogen for 2 h. The reaction was filtered through Celite with more EtOH and concentrated to afford the title compound (0.45 g). MS 581 (M+1).

出典