反応 #483785

反応方程式

4-piperidone monohydrate hydrochloride

AlCl3

benzene

water

→

off-white solid

収率 72.0%

4,4-Diphenylpiperidine hydrochloride

収率 72.0%

反応条件

後処理

1. 1
   温度at reflux for 4 hours
2. 2
   ろ過filtered
3. 3
   洗浄The solid was washed with toluene
4. 4
   その他dried

実験手順

A mixture of 4-piperidone monohydrate hydrochloride (15.0 g, 97.6 mmol, 1.00 equiv) and AlCl3 (130 g, 976 mmol, 10.0 equiv) in anhydrous benzene (600 mL) was stirred at reflux for 4 hours. The mixture was cooled to room temperature, poured into ice (300 g) and water (50 mL), and filtered. The solid was washed with toluene and dried to afford 19.2 g (72%) of off-white solid, which was characterized spectroscopically.

出典