反応 #48353

反応方程式

3,4-diaminopyridine

1-benzyl-4-piperidone

acetic acid

→

title compound

収率 98.2%

4-Amino-3-[(1-benzylpiperidin-4-yl)amino)pyridine

収率 98.2%

溶媒

dichloroethane

反応条件

後処理

1. 1
   濃縮The reaction was concentrated
2. 2
   その他partitioned between chloroform (5×50 mL) and 1N sodium hydroxide (50 mL)
3. 3
   乾燥The organic phase was dried over magnesium sulfate
4. 4
   濃縮concentrated

実験手順

A mixture of 3,4-diaminopyridine (1.1 g, 10.1 mmol), 1-benzyl-4-piperidone (3.2 g, 16.9 mmol) sodium triacetoxyborohydride (4.0 g, 18.9 mmol), and acetic acid (10.7 mL) in dichloroethane (10 mL) was stirred for about 6 days at room temperature. The reaction was concentrated to near dryness, and partitioned between chloroform (5×50 mL) and 1N sodium hydroxide (50 mL). The organic phase was dried over magnesium sulfate and concentrated to give the title compound (2.8 g). MS 283 (M+1).

出典