反応 #48274

反応方程式

potassium (E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate

DMF

4-bromobutylnitrate

→

(E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-(nitrooxy)butyl ester

収率 70.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   workup.STIRRINGunder stirring for 136 h

実験手順

A mixture of potassium (E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate (2.07 g; 9 mmol), obtained in the previous step, DMF (8.3 g), KI (0.5 g) and a 20% w/w solution (82.5 g) of 4-bromobutylnitrate (16.5 g; 16.7 mmol) in CH2Cl2 is heated under stirring to 40° C. and kept at this temperature under stirring for 136 h. After work up, (E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-(nitrooxy)butyl ester was obtained in 70% yield.

出典