反応 #482671

ord-693bfef3b7fb4e6a90cacb23c0d4a001

反応方程式

COc1cc(-c2cc(CN3CCC(=O)CC3)ccn2)cc(OC)c1OC
1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone
CSc1cccc(N)c1
3-methylthioaniline
COc1cc(-c2cc(CN3CCC(Nc4cccc(SC)c4)CC3)ccn2)cc(OC)c1OC
title compound
COc1cc(-c2cc(CN3CCC(Nc4cccc(SC)c4)CC3)ccn2)cc(OC)c1OC
4-(3-Methylthioanilino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他as described in Preparation Example 37

実験手順

1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (1.40 g) and 3-methylthioaniline (655 mg) were reacted in the same manner as described in Preparation Example 37 to give the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06605620B1uspto-grants-2003_08