反応 #481926

反応方程式

6-amino-4-[(3-bromophenyl)amino]quinazoline

trans-crotonyl chloride

→

title compound

収率 52.0%

N-[4-[(3-Bromophenyl)amino]quinazolin-6-yl]-E-but-2-enamide

収率 52.0%

溶媒

THF

反応条件

後処理

1. 1
   その他A yellow solid formed upon addition
2. 2
   ろ過The solid was collected by Buchner filtration after 2.5 hours
3. 3
   その他sonicated with EtOAc

実験手順

To a solution of 6-amino-4-[(3-bromophenyl)amino]quinazoline (316 mg, 1.0 mmol) in THF (6 mL) stirred under N2 at 0° C. was added trans-crotonyl chloride. A yellow solid formed upon addition. The solid was collected by Buchner filtration after 2.5 hours and sonicated with EtOAc to give the title compound (216 mg, 52%), mp 279-281° C.

出典