反応 #48165

反応方程式

[6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

[6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

2-chloropyridine-4-boronic acid

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title compound

[6-Bromo-1-(2-chloro-pyridin-4-yl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

反応条件

後処理

1. 1
   その他In analogy to the procedure described for the synthesis of example 6

実験手順

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from [6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone (example 41, step 6) and 2-chloropyridine-4-boronic acid. The title compound was obtained in 12% yield as light yellow oil. MS (m/e): 561.4 (MH+, 100%).

出典