反応 #4816

反応方程式

chloromethyl n-dodecanoate

quinuclidine

KBr

→

n-Dodecanoyloxymethylquinuclidinium Chloride

溶媒

ether

反応条件

後処理

1. 1
   その他to react together at room temperature for 48 hrs
2. 2
   その他the mixture was triturated in anydrous ether overnite
3. 3
   その他The solid was isolated by filtration under a nitrogen atmosphere
4. 4
   洗浄thoroughly washed with anhydrous ether
5. 5
   乾燥After drying in vacuo over calcium sulfate at room temperature
6. 6
   その他2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

実験手順

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

出典