反応 #48149

反応方程式

[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

intermediate 2

[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

4-cyanophenylboronic acid

→

title compound

4-[5-(1-Isopropyl-piperidin-4-yloxy)-2-(morpholine-4-carbonyl)-indol-1-yl]-benzonitrile

反応条件

後処理

1. 1
   その他In analogy to the procedure described for the synthesis of example 6

実験手順

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from [5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone (intermediate 2) and 4-cyanophenylboronic acid. The title compound was obtained in 31% yield as yellow foam. MS (m/e): 473.2 (MH+, 100%).

出典