反応 #48132
ord-4166aa5584244dbf94d7afcf1d04cac5
反応方程式
(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
intermediate 1
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
3-fluorobenzeneboronic acid
→
title compound
(4,4-Difluoro-piperidin-1-yl)-[1-(3-fluoro-phenyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
反応物
(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
intermediate 1
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
3-fluorobenzeneboronic acid
試薬
なし
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他In analogy to the procedure described for the synthesis of example 6
実験手順
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 3-fluorobenzeneboronic acid. The title compound was obtained in 97% yield as yellow foam. MS (m/e): 500.1 (MH+, 100%).