反応 #4813

反応方程式

ethyl nicotinate

chloromethyl benzoate

→

1-benzoyloxymethyl-3-carboethoxypyridinium chloride

反応条件

後処理

1. 1
   温度was heated at 70° under nitrogen for 10 hrs
2. 2
   その他Trituration in anhydrous ether and recrystallization from ethanol-ether

実験手順

A mixture of 3.00 g (0.02 mol) ethyl nicotinate and 3.50 g (0.02 mol) chloromethyl benzoate was heated at 70° under nitrogen for 10 hrs. Trituration in anhydrous ether and recrystallization from ethanol-ether gave 2.18 g (0.007 mol), 35%, 1-benzoyloxymethyl-3-carboethoxypyridinium chloride, mp 138°-141°; ir (KBr) 1730 cm-1 ; pmr (CDCl3) δ 1.43 (t, 3H), 4.47 (q, 2H), 7.7-7.3 (m, 5H), 8.2-7.95 (m, 2H), 9.17-8.50 (m, 4), 10.0 (bs, 1H) and 10.2 (bd, 1H) ppm.

出典