反応 #48098

反応方程式

water

4-bromo-3-chloromethyl-1-iodo-benzene

Phenol

NaI

→

4-Bromo-1-iodo-3-phenoxymethyl-benzene

溶媒

acetone

KOH

反応条件

後処理

1. 1
   抽出the resulting mixture is extracted with ethyl acetate
2. 2
   その他The combined extracts are dried
3. 3
   その他the solvent is evaporated under reduced pressure
4. 4
   その他The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1)

実験手順

Phenol (13 g) dissolved in 4 M KOH solution (60 mL) is added to 4-bromo-3-chloromethyl-1-iodo-benzene (41.0 g) dissolved in acetone (50 mL). NaI (0.5 g) is added and the resulting mixture is stirred at 50° C. overnight. Then, water is added and the resulting mixture is extracted with ethyl acetate. The combined extracts are dried and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1).

出典