反応 #48097

反応方程式

Thionyl chloride

4-bromo-3-hydroxymethyl-1-iodo-benzene

DMF

→

4-Bromo-3-chloromethyl-1-iodo-benzene

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他Then, the solvent and the excess reagent is removed under reduced pressure
2. 2
   その他The residue is triturated with methanol
3. 3
   その他dried

実験手順

Thionyl chloride (13 mL) is added to a suspension of 4-bromo-3-hydroxymethyl-1-iodo-benzene (47.0 g) in dichloromethane (100 mL) containing DMF (0.1 mL). The mixture is stirred at ambient temperature for 3 h. Then, the solvent and the excess reagent is removed under reduced pressure. The residue is triturated with methanol and dried.

出典