反応 #48078

反応方程式

4-bromo-1-chloro-2-isopropenylbenzene

→

desired product

収率 72.3%

4-bromo-1-chloro-2-isopropylbenzene

収率 72.3%

溶媒

toluene

反応条件

後処理

1. 1
   ろ過The reaction mixture was then filtered through celite®
2. 2
   その他the filtrate was evaporated to dryness

実験手順

A mixture of 4-bromo-1-chloro-2-isopropenylbenzene (357 mg, 1.54 mmol, 1 eq) and PtO2 (35 mg, 0.15 mmol, 0.1 eq) in 4 ml toluene was stirred under an atmosphere of hydrogen at RT overnight. The reaction mixture was then filtered through celite® and the filtrate was evaporated to dryness to give the desired product (260 mg, 72%). 1H NMR (CDCl3, 300 MHz): 7.39 (d, J=2 Hz, 1H), 7.26-7.16 (m, 2H), 3.35 (sept, J=7 Hz, 1H), 1.23 (d, J=7 Hz, 6H).

出典