反応 #480774

反応方程式

5-Benzyloxy-2-fluoro-4-methyl-1-nitrobenzene

hydrazine hydrate

→

5-benzyloxy-2-fluoro-4-methylaniline

収率 100.1%

溶媒

methanol

methanol

反応条件

後処理

1. 1
   温度heated
2. 2
   温度at reflux
3. 3
   温度The mixture was maintained
4. 4
   温度under reflux for 15 minutes
5. 5
   その他the insoluble materials removed by filtration through diatomaceous earth
6. 6
   洗浄The filter pad was washed with methanol
7. 7
   その他the solvent removed from the filtrate by evaporation

実験手順

5-Benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (500 mg, 1.9 mmol) in methanol (110 ml) was added to a suspension of Raney nickel (75 mg) and hydrazine hydrate (0.47 ml, 9.5 mmol) in methanol (10 ml) and heated at reflux. The mixture was maintained under reflux for 15 minutes and then the insoluble materials removed by filtration through diatomaceous earth. The filter pad was washed with methanol and the solvent removed from the filtrate by evaporation to give 5-benzyloxy-2-fluoro-4-methylaniline (440 mg, 99%).

出典