反応 #480773

反応方程式

4-fluoro-2-methyl-5-nitrophenol

benzyl bromide

potassium carbonate

→

5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene

収率 90.7%

溶媒

DMF

water

反応条件

後処理

1. 1
   温度to cool
2. 2
   ろ過The precipitated product was collected by filtration
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

A mixture of 4-fluoro-2-methyl-5-nitrophenol (4.69 g, 27 mmol), benzyl bromide (3.59 ml, 30 mmol) and potassium carbonate (7.58 g, 55 mmol) in DMF (100 ml) was heated at 80° C. for 4 hours. The mixture was allowed to cool and diluted with water and stirred for 15 minutes. The precipitated product was collected by filtration, washed with water and dried to give 5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (6.4 g, 89%).

出典