反応 #4806

反応方程式

N-methyl-1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

N-methyl-1-(3-methylphenyl)-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

allyl phenyl ether

allyl 3-methylphenyl ether

→

title compound

3-Phenyl-3-(1H-1,2,4-triazol-1-yl)methyl-2-methyl-5-(phenoxymethyl)isoxazolidine

反応条件

後処理

1. 1
   その他was flash-chromatographed on neutral silica gel

実験手順

Compound 3 (R1 =R2 =H) was prepared by a procedure similar to that described in Example 1 by reacting N-methyl-1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1, R1 =H) with allyl phenyl ether (2, R2 =H). The resulting cis- and trans-diastereomeric mixture of the title compound was flash-chromatographed on neutral silica gel using chloroform-methanol (99:1 by volume) as eluent. Isomer A has a melting point 68°-75° C. (ethyl acetate-hexane, 1:1 by volume).

出典