反応 #48028

反応方程式

N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride

→

N-[2-chloro-3-(1-piperidinyl)propoxy]-3-pyridine-carboximidamide dihydrochloride

溶媒

thionyl chloride

反応条件

後処理

1. 1
   その他the mixture was evaporated to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in 300 ml of methanol
3. 3
   workup.ADDITIONtreated with charcoal
4. 4
   ろ過after filtration the solvent
5. 5
   その他was evaporated in reduced pressure
6. 6
   workup.DISSOLUTIONThe residue was dissolved in the minimum amount of ethanol

実験手順

17.5 g (0.05 mole) of N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride was dissolved in 50 ml of thionyl chloride, boiled for one hour, then the mixture was evaporated to dryness. The residue was dissolved in 300 ml of methanol, treated with charcoal and after filtration the solvent was evaporated in reduced pressure. The residue was dissolved in the minimum amount of ethanol and refrigerated to yield crystalline N-[2-chloro-3-(1-piperidinyl)propoxy]-3-pyridine-carboximidamide dihydrochloride as intermediate compound.

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