反応 #4797

反応方程式

2-(3-methyl-4-propoxy-2-pyridyl)methylthiobenzimidazole

m-chloroperbenzoic acid

→

2-[3-methyl-4-propoxy-2-pyridyl)methylsulfinylbenzimidazole

収率 39.5%

溶媒

chloroform

chloroform

反応条件

後処理

1. 1
   その他The solution was chromatographed directly on a column of silica gel (50 g), which
2. 2
   洗浄was eluted with ethyl acetatehexane (1:1)
3. 3
   その他From the eluate was removed the solvent
4. 4
   その他The residue was recrystallized from acetone-ether-hexane

実験手順

To a solution of 2-(3-methyl-4-propoxy-2-pyridyl)methylthiobenzimidazole (1 g) in chloroform (20 ml) was added dropwise over 10 minutes under ice-cooling m-chloroperbenzoic acid (750 mg) dissolved in chloroform (10 ml). The solution was chromatographed directly on a column of silica gel (50 g), which was eluted with ethyl acetatehexane (1:1) and then with 5% methanol-ethyl acetate. From the eluate was removed the solvent. The residue was recrystallized from acetone-ether-hexane to give 415 mg of 2-[3-methyl-4-propoxy-2-pyridyl)methylsulfinylbenzimidazole.4/5H2O as crystals, m.p. 81°-83° C.

出典