反応 #47891

反応方程式

1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione

compound F1

1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione

thiosemicarbazide

→

5-(4-Iodo-phenyl)-6H-pyrazolo[1,5-c]pyrimidine-7-thione

溶媒

methanol

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度to reflux temperature
3. 3
   ろ過is filtered
4. 4
   洗浄washed with methanol
5. 5
   その他The filtrate with the product is purified by flash silica gel chromatography

実験手順

A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.

出典