反応 #47843

反応方程式

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

benzylamine

sodium iodide

→

titled compound

収率 44.0%

1-benzylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

収率 44.0%

溶媒

THF

反応条件

後処理

1. 1
   温度by refluxing for 6 hrs
2. 2
   洗浄The resulting mixture washed with saturated saline
3. 3
   抽出extracted with ethyl acetate
4. 4
   その他The organic layer was separated
5. 5
   乾燥dried over anhydrous MgSO4
6. 6
   濃縮concentrated under a reduced pressure
7. 7
   その他The resulting residue was purified by flash chromatography

実験手順

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (120 mg, 0.32 mmol) obtained in Example 18 was dissolved in THF (10 mL), and benzylamine (102.87 mg, 0.11 mL, 0.93 mmol) and sodium iodide (9.60 mg, 0.06 mmol) were added thereto, followed by refluxing for 6 hrs. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 56 mg of the titled compound (yield: 44%).

出典