反応 #47841

反応方程式

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethylamine

→

titled compound

収率 75.6%

1-ethylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

収率 75.6%

溶媒

THF

THF

反応条件

後処理

1. 1
   その他the solvent was removed under a reduced pressure
2. 2
   その他The resulting residue was purified by flash chromatography

実験手順

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and 2.0 M ethylamine (0.68 mL, 1.35 mmol) in THF was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 68 mg of the titled compound (yield: 75.6%).

出典