反応 #47830

反応方程式

1-Hydroxyimino-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester

1-hydroxyimino-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

→

titled compound

収率 78.0%

1-amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

収率 78.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他while providing H2 gas
2. 2
   ろ過filtered through celite
3. 3
   濃縮concentrated under a reduced pressure
4. 4
   その他The resulting residue was purified by flash chromatography

実験手順

1-Hydroxyimino-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester (0.5 g, 1.17 mmol) obtained in Step 1 was dissolved in methanol (30 mL) and 10%-palladium (400 mg) was added thereto. The mixture was stirred for 15 hrs at RT while providing H2 gas thereto using a balloon, filtered through celite, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 377 mg of the titled compound (yield: 78%).

出典