反応 #47826

反応方程式

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

収率 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

収率 52.0%

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   その他The organic layer was separated
3. 3
   濃縮concentrated under a reduced pressure
4. 4
   その他The resulting residue was purified by flash chromatography

実験手順

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

出典