反応 #47817

反応方程式

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester

p-toluenesulfonic acid

→

titled compound

収率 62.1%

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

収率 62.1%

溶媒

methanol

反応条件

後処理

1. 1
   温度refluxed for 24 hrs
2. 2
   洗浄The resulting mixture washed with sodium bicarbonate
3. 3
   抽出extracted with ethyl acetate
4. 4
   その他The organic layer was separated
5. 5
   乾燥dried over anhydrous MgSO4
6. 6
   濃縮concentrated under a reduced pressure
7. 7
   その他Then, the resulting residue was purified by flash chromatography

実験手順

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester (2 g, 4.85 mmol) obtained in Example 7 was dissolved in methanol, p-toluenesulfonic acid (92 mg, 0.49 mmol) was added thereto, and refluxed for 24 hrs. The resulting mixture washed with sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 1.2 g of the titled compound (yield: 62%).

出典