反応 #47810

反応方程式

6-(2-Morpholine-4-ylethoxy)-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

6-(2-morpholine-4-ylethoxy)-1-oxo-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

phenylmagnesium chloride

→

titled compound

収率 44.1%

1-hydroxy-6-(2-morpholine-4-yl-ethoxy)-1,3-diphenyl-1H-indene-2-carboxylic Acid Ethyl Ester

収率 44.1%

溶媒

THF

反応条件

後処理

1. 1
   洗浄The resulting mixture washed with saturated saline
2. 2
   抽出extracted with ethyl acetate
3. 3
   その他The organic layer was separated
4. 4
   乾燥dried over anhydrous MgSO4
5. 5
   濃縮concentrated under a reduced pressure
6. 6
   その他The resulting residue was purified by flash chromatography

実験手順

6-(2-Morpholine-4-ylethoxy)-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.5 g, 3.68 mmol) obtained in Step 1 was dissolved in THF, and phenylmagnesium chloride (3.865 mL, 5.89 mmol) was added thereto, followed by stirring for 2 hrs at 0° C. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 788 mg of the titled compound (yield: 44%).

出典