反応 #47807

反応方程式

1-bromo-3-phenyl propane

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

potassium carbonate

sodium iodide

→

titled compound

収率 85.0%

1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

収率 85.0%

溶媒

N,N-dimethyl formamide

反応条件

後処理

1. 1
   洗浄The resulting mixture washed with saturated ammonium chloride
2. 2
   抽出extracted with ethyl acetate
3. 3
   その他The organic layer was separated
4. 4
   乾燥dried over anhydrous MgSO4
5. 5
   濃縮concentrated under a reduced pressure
6. 6
   その他Then, the resulting residue was purified by flash chromatography

実験手順

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (2 g, 6.79 mmol) prepared in Preparation Example 2, potassium carbonate (1.40 g, 10.19 mmol) and sodium iodide (0.2 g, 1.39 mmol) were dissolved in N,N-dimethyl formamide, and 1-bromo-3-phenyl propane (2.066 ml, 13.592 mmol) was added thereto, followed by stirring for 8 hrs at room temperature. The resulting mixture washed with saturated ammonium chloride and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 2.37 g of the titled compound (yield: 85%) as a dark red solid.

出典