反応 #47802

反応方程式

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

3-methoxyphenylmagnesium bromide

→

titled compound

収率 90.4%

1-hydroxy-6-methoxy-1-(3-methoxy-phenyl)-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

収率 90.4%

溶媒

THF

反応条件

後処理

1. 1
   洗浄Then, the reaction mixture washed with saturated saline
2. 2
   抽出extracted with ethyl acetate
3. 3
   その他The organic layer was separated
4. 4
   乾燥dried over anhydrous MgSO4
5. 5
   濃縮concentrated under a reduced pressure
6. 6
   その他The resulting residue was purified by flash chromatography

実験手順

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.325 mmol) obtained in Example 1 was dissolved in THF and 1.5 equivalents of 3-methoxyphenylmagnesium bromide were added thereto, followed by stirring for 1 hr at 0° C. Then, the reaction mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 122 mg of the titled compound (yield: 90.4%).

出典