反応 #47744

反応方程式

arecoline hydrochloride

HCl

→

product

収率 46.0%

Arecaidine hydrochloride

収率 46.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他In a 250 ml flask equipped with a magnetic stirrer and a condenser
2. 2
   温度at reflux for 6 hours
3. 3
   その他The solvents are evaporated off under reduced pressure
4. 4
   その他leaving a solid residue
5. 5
   その他The residue is recrystallized from a 95% ethanol/ether mixture in order

実験手順

In a 250 ml flask equipped with a magnetic stirrer and a condenser, arecoline hydrochloride (4 g; 20.9 mmol) is added to a solution of 50 ml of 95% ethanol and 60 ml of concentrated HCl. The mixture is heated at 100° C. for 12 hours then at reflux for 6 hours. The solvents are evaporated off under reduced pressure leaving a solid residue. The residue is recrystallized from a 95% ethanol/ether mixture in order to produce 1.69 g of product (Yield=46%) in the form of white crystals.

出典