反応 #47703

反応方程式

ethyl acetate

N,N-diethyl-2-(3-formyl-1H-indol-1-yl)acetamide

piperidine

2,3-dihydro-1H-indolizinium chloride

→

1-({1-[2-(Diethylamino)-2-oxoethyl]-1H-indol-3-yl}methylene)-2,3-dihydro-1H-indolizinium chloride

溶媒

isopropanol

isopropanol

反応条件

後処理

1. 1
   その他The reaction mixtures
2. 2
   その他to precipitate the dye
3. 3
   ろ過The precipitate was filtered off
4. 4
   洗浄washed with 3 times with 25 ml of ethyl acetate
5. 5
   その他before being dried under vacuum until a constant weight
6. 6
   その他was obtained
7. 7
   その他1.09 g of orange powder were recovered

実験手順

0.800 g of N,N-diethyl-2-(3-formyl-1H-indol-1-yl)acetamide was solubilized in 4.2 ml of isopropanol. 0.238 g of piperidine was added, followed by 0.435 g of 2,3-dihydro-1H-indolizinium chloride dissolved in 7 ml of isopropanol. The reaction mixtures were brought to 80° C. for 24 h, with stirring. 50 ml of ethyl acetate were added in order to precipitate the dye. The precipitate was filtered off, and washed with 3 times with 25 ml of ethyl acetate before being dried under vacuum until a constant weight was obtained. 1.09 g of orange powder were recovered. The analyses were in conformity with the expected structure.

出典