反応 #47601

反応方程式

2-acetylamino-2-(2,2-difluoro-ethyl)-malonic acid diethyl ester

hydrochloric acid

→

2-amino-4,4-difluoro-butyric acid hydrochloride salt

収率 97.0%

反応条件

後処理

1. 1
   その他In a flask was placed
2. 2
   温度This mixture was refluxed overnight
3. 3
   抽出extracted with diethyl ether (100 mL) the aqueous layer
4. 4
   濃縮was concentrated in vacuo
5. 5
   その他azeotroped with acetonitrile
6. 6
   その他dried under high vacuum

実験手順

In a flask was placed 2-acetylamino-2-(2,2-difluoro-ethyl)-malonic acid diethyl ester (8.94 g, 31.78 mmol) and 6N aqueous hydrochloric acid (140 mL). This mixture was refluxed overnight. After this time, the mixture was cooled to room temperature and extracted with diethyl ether (100 mL) the aqueous layer was concentrated in vacuo, azeotroped with acetonitrile and dried under high vacuum to afford 2-amino-4,4-difluoro-butyric acid hydrochloride salt (5.39 g, 97%) as a cream colored solid.

出典