反応 #4744

反応方程式

ammonia

3-hydroxybenzaldehyde

3-methylpiperidine

formic acid

→

3-[(3-Methylpiperidin-1-yl)methyl]phenol

溶媒

water

反応条件

後処理

1. 1
   温度with cooling
2. 2
   温度When the reaction mixture has cooled to room temperature
3. 3
   ろ過the precipitated solid is filtered off
4. 4
   その他recrystallised from ethanol

実験手順

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

出典