反応 #474309

ord-4f4795cc08cc48dbab872608382309ca

反応方程式

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
CCCc1cc(CCC=O)n(C(C)(C)C)n1
3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal
Cc1cccc(N2CCNCC2)c1C
1-(2,3-dimethylphenyl)piperazine
CCN(C(C)C)C(C)C
DIPEA
→
CCCc1cc(CCCN2CCN(c3cccc(C)c3C)CC2)n(C(C)(C)C)n1
1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2,3-dimethylphenyl)piperazine

反応物

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
CCCc1cc(CCC=O)n(C(C)(C)C)n1
3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal
Cc1cccc(N2CCNCC2)c1C
1-(2,3-dimethylphenyl)piperazine
CCN(C(C)C)C(C)C
DIPEA

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他158 mg (81%) of target compound was obtained

実験手順

158 mg (81%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.450 mmol), 1-(2,3-dimethylphenyl)piperazine (86 mg, 0.450 mmol), DIPEA (0.118 mL, 0.675 mmol) and NaBH(OAc)3 (286 mg, 1.350 mmol).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08372844B2uspto-grants-2013_02