反応 #474305

反応方程式

NaBH(OAc)3

3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal

1-(2-fluorophenyl)piperazine

DIPEA

→

1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(2-fluorophenyl)piperazine

反応条件

後処理

1. 1
   その他171 mg (90%) of target compound was obtained

実験手順

171 mg (90%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.450 mmol), 1-(2-fluorophenyl)piperazine (81 mg, 0.450 mmol), DIPEA (0.118 mL, 0.675 mmol) and NaBH(OAc)3 (286 mg, 1.350 mmol).

出典